Deficiency of thrombospondin‐1 in mice does not affect adipose tissue development
G Voros, HR Lijnen - Journal of Thrombosis and Haemostasis, 2006 - jthjournal.org
Thrombospondin-1 (TSP-1) is a 420 kDa matricellular glycoprotein released by platelets
during the formation of a hemostatic plug. It has been implicated in cell–matrix and cell–cell
interactions that play an important role in platelet function, angiogenesis, tumor biology,
wound healing and vascular disease [1]. Despite this pleiotropic biological role, mice
deficient in TSP-1 are viable and exhibit only subtle abnormalities in development, although
they develop pneumonia [2], and show delayed organization and prolonged …
during the formation of a hemostatic plug. It has been implicated in cell–matrix and cell–cell
interactions that play an important role in platelet function, angiogenesis, tumor biology,
wound healing and vascular disease [1]. Despite this pleiotropic biological role, mice
deficient in TSP-1 are viable and exhibit only subtle abnormalities in development, although
they develop pneumonia [2], and show delayed organization and prolonged …