[PDF][PDF] The eIF4E-binding proteins 1 and 2 are negative regulators of cell growth
Initiation in eukaryotes is the rate limiting step of translation. The binding of the mRNA to the
40S ribosomal subunit, which is mediated by the mRNA cap structure, is a key target for
control of protein synthesis. The cap binding protein, eIF4E, is the most limiting of all
initiation factors and its overexpression in NIH3T3 cells causes malignant transformation. 4E-
binding protein 1 (BP1) and 4E-BP2 are small proteins that bind to eIF4E and inhibit
translation. Here, 4E-BPs were expressed in cells transformed by eIF4E or by v-src to …
40S ribosomal subunit, which is mediated by the mRNA cap structure, is a key target for
control of protein synthesis. The cap binding protein, eIF4E, is the most limiting of all
initiation factors and its overexpression in NIH3T3 cells causes malignant transformation. 4E-
binding protein 1 (BP1) and 4E-BP2 are small proteins that bind to eIF4E and inhibit
translation. Here, 4E-BPs were expressed in cells transformed by eIF4E or by v-src to …