Prostate cancer prevention
WG Nelson - Current opinion in urology, 2007 - journals.lww.com
Current opinion in urology, 2007•journals.lww.com
The contributions of infection and inflammation to the early development of prostate cancer
suggest prevention strategies featuring prevention or eradication of infection, amelioration of
inflammation, or attenuation of genome-damaging reactive oxygen and nitrogen species.
The acquisition of androgen dependence later during prostate cancer pathogenesis
suggests the use of approaches targeting androgen signaling, including inhibitors of 5α-
reductase.
suggest prevention strategies featuring prevention or eradication of infection, amelioration of
inflammation, or attenuation of genome-damaging reactive oxygen and nitrogen species.
The acquisition of androgen dependence later during prostate cancer pathogenesis
suggests the use of approaches targeting androgen signaling, including inhibitors of 5α-
reductase.
Summary
The contributions of infection and inflammation to the early development of prostate cancer suggest prevention strategies featuring prevention or eradication of infection, amelioration of inflammation, or attenuation of genome-damaging reactive oxygen and nitrogen species. The acquisition of androgen dependence later during prostate cancer pathogenesis suggests the use of approaches targeting androgen signaling, including inhibitors of 5α-reductase.
Lippincott Williams & Wilkins