[HTML][HTML] Protein phosphatase 2A regulates apoptosis in neutrophils by dephosphorylating both p38 MAPK and its substrate caspase 3
M Alvarado-Kristensson, T Andersson - Journal of Biological Chemistry, 2005 - ASBMB
The induction of apoptosis in neutrophils is an essential event in the resolution of an
inflammatory process. We found recently that the reduction of the activity of the neutrophil
survival factor p38 MAPK and dephosphorylation and thus activation of caspases must occur
to initiate such cell death in these leukocytes. Here, we report a previously undetected early
and transient activation of protein phosphatase 2A (PP2A) in neutrophils undergoing
apoptosis. The pharmacological inhibition of this phosphatase during Fas-induced …
inflammatory process. We found recently that the reduction of the activity of the neutrophil
survival factor p38 MAPK and dephosphorylation and thus activation of caspases must occur
to initiate such cell death in these leukocytes. Here, we report a previously undetected early
and transient activation of protein phosphatase 2A (PP2A) in neutrophils undergoing
apoptosis. The pharmacological inhibition of this phosphatase during Fas-induced …
