Prevalence of coronary heart disease associated with HFE mutations in adults attending a health appraisal center
J Waalen, V Felitti, T Gelbart, NJ Ho… - The American journal of …, 2002 - Elsevier
PURPOSE: Mutations of the HFE gene that cause hereditary hemochromatosis may be
associated with an increased risk of cardiovascular disease. We examined the relation
between two HFE mutations (C282Y and H63D), indicators of iron homeostasis, and the
prevalence of coronary heart disease in a large population of white adults. SUBJECTS AND
METHODS: We conducted a cross-sectional study of 30,916 white adults aged 25 to 98
years who attended a health appraisal center and underwent screening for HFE mutations …
associated with an increased risk of cardiovascular disease. We examined the relation
between two HFE mutations (C282Y and H63D), indicators of iron homeostasis, and the
prevalence of coronary heart disease in a large population of white adults. SUBJECTS AND
METHODS: We conducted a cross-sectional study of 30,916 white adults aged 25 to 98
years who attended a health appraisal center and underwent screening for HFE mutations …
