Recent results indicate that the longevity of both invertebrates and vertebrates can be
altered through genetic manipulation and pharmacological intervention. Most of these
interventions involve alterations of one or more of the following: insulin/IGF-I signaling
pathway, caloric intake, stress resistance and nuclear structure. How longevity regulation
relates to aging per se is less clear, but longevity increases are usually accompanied by
extended periods of good health. How these results will translate to primate aging and …