[HTML][HTML] Calpain-mediated X-linked inhibitor of apoptosis degradation in neutrophil apoptosis and its impairment in chronic neutrophilic leukemia
S Kobayashi, K Yamashita, T Takeoka, T Ohtsuki… - Journal of Biological …, 2002 - ASBMB
The number of neutrophils in the blood and tissues is controlled by constitutive apoptotic
programmed cell death and clearance by phagocytes such as macrophages. Here, we
found that calpains cleave the X-linked inhibitor of apoptosis (XIAP) in vitro, producing
fragments that are unable to inhibit caspase-3. These fragments were detected in normal
neutrophils but were unstable and rapidly degraded. Calpain inhibition delayed tumor
necrosis factor-α-induced apoptosis of normal neutrophils, consistent with a role for calpains …
programmed cell death and clearance by phagocytes such as macrophages. Here, we
found that calpains cleave the X-linked inhibitor of apoptosis (XIAP) in vitro, producing
fragments that are unable to inhibit caspase-3. These fragments were detected in normal
neutrophils but were unstable and rapidly degraded. Calpain inhibition delayed tumor
necrosis factor-α-induced apoptosis of normal neutrophils, consistent with a role for calpains …
