The human thyrotropin receptor activates G-proteins Gs and Gq/11.
A Allgeier, S Offermanns, J Van Sande… - Journal of Biological …, 1994 - ASBMB
The human thyrotropin receptor leads upon activation to the stimulation of phospholipase C
and adenylyl cyclase. It is presently not known whether this bifurcating signaling occurs via
two different G-proteins (Gq/11 and Gs) or via one G-protein (Gs). Receptor-activated Gs
releases beta gamma subunits and alpha s, which then could regulate phospholipase C and
adenylyl cyclase, respectively. In order to elucidate the signaling pathways induced by the
activated thyroid-stimulating hormone (TSH) receptor, we studied the coupling of the TSH …
and adenylyl cyclase. It is presently not known whether this bifurcating signaling occurs via
two different G-proteins (Gq/11 and Gs) or via one G-protein (Gs). Receptor-activated Gs
releases beta gamma subunits and alpha s, which then could regulate phospholipase C and
adenylyl cyclase, respectively. In order to elucidate the signaling pathways induced by the
activated thyroid-stimulating hormone (TSH) receptor, we studied the coupling of the TSH …
