Characterization of the hypotensive effect of S-nitroso-N-acetylcysteine in normotensive and hypertensive conscious rats
KFS Ricardo, SM Shishido, MG de Oliveira, MH Krieger - Nitric Oxide, 2002 - Elsevier
S-Nitrosothiols (RSNOs) are potent vasodilators found naturally in vivo. A variety of synthetic
RSNOs have been considered as potential nitric oxide (NO) donors for biomedical
applications. We have characterized the hypotensive effect of the RSNO S-nitroso-N-
acetylcysteine (SNAC) in normotensive and hypertensive conscious rats. SNAC reduced the
medium arterial pressure in a dose–response manner in both normotensive and
hypertensive animals. At the same doses (EC50 of SNAC), SNAC showed a vasodilator …
RSNOs have been considered as potential nitric oxide (NO) donors for biomedical
applications. We have characterized the hypotensive effect of the RSNO S-nitroso-N-
acetylcysteine (SNAC) in normotensive and hypertensive conscious rats. SNAC reduced the
medium arterial pressure in a dose–response manner in both normotensive and
hypertensive animals. At the same doses (EC50 of SNAC), SNAC showed a vasodilator …
