Mechanisms and models in heart failure: the biomechanical model and beyond
DL Mann, MR Bristow - Circulation, 2005 - Am Heart Assoc
DL Mann, MR Bristow
Circulation, 2005•Am Heart Assocresultant striking increase in morbidity and mortality. The transition to symptomatic heart
failure is accompanied by further activation of neurohormonal and cytokine systems, as well
as a series of adaptive changes within the myocardium, collectively referred to as “LV
remodeling.” Although there are further modest declines in the overall pumping capacity of
the heart during the transition to symptomatic heart failure, the weight of experimental and
clinical evidence suggests that heart failure progression occurs independently of the …
failure is accompanied by further activation of neurohormonal and cytokine systems, as well
as a series of adaptive changes within the myocardium, collectively referred to as “LV
remodeling.” Although there are further modest declines in the overall pumping capacity of
the heart during the transition to symptomatic heart failure, the weight of experimental and
clinical evidence suggests that heart failure progression occurs independently of the …
resultant striking increase in morbidity and mortality. The transition to symptomatic heart failure is accompanied by further activation of neurohormonal and cytokine systems, as well as a series of adaptive changes within the myocardium, collectively referred to as “LV remodeling.” Although there are further modest declines in the overall pumping capacity of the heart during the transition to symptomatic heart failure, the weight of experimental and clinical evidence suggests that heart failure progression occurs independently of the hemodynamic status of the patient.
Am Heart Assoc
