Cloning and analysis of the thrombopoietin-induced megakaryocyte-specific glycoprotein VI promoter and its regulation by GATA-1, Fli-1, and Sp1
ML Holmes, N Bartle, M Eisbacher… - Journal of Biological …, 2002 - ASBMB
The exposure of collagen fibers at sites of vascular injury results in the adherence of
platelets and their subsequent activation. The platelet collagen receptor glycoprotein (GP) 1
VI plays a crucial role in platelet activation and thrombus formation and decreased levels or
defective GPVI may lead to excessive bleeding. In addition, elevated levels of collagen
receptors may predispose individuals to coronary heart disease or strokes. GPVI expression
is restricted to platelets and their precursor cell, the megakaryocyte. In this study we …
platelets and their subsequent activation. The platelet collagen receptor glycoprotein (GP) 1
VI plays a crucial role in platelet activation and thrombus formation and decreased levels or
defective GPVI may lead to excessive bleeding. In addition, elevated levels of collagen
receptors may predispose individuals to coronary heart disease or strokes. GPVI expression
is restricted to platelets and their precursor cell, the megakaryocyte. In this study we …
