Sphingosine-1-phosphate: an enigmatic signalling lipid
S Spiegel, S Milstien - Nature reviews Molecular cell biology, 2003 - nature.com
S Spiegel, S Milstien
Nature reviews Molecular cell biology, 2003•nature.comThe evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-
phosphate (S1P), in yeast, plants and mammals have shown that it has important functions.
In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors.
These S1P receptors are differentially expressed, coupled to various G proteins, and
regulate angiogenesis, vascular maturation, cardiac development and immunity, and are
important for directed cell movement.
phosphate (S1P), in yeast, plants and mammals have shown that it has important functions.
In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors.
These S1P receptors are differentially expressed, coupled to various G proteins, and
regulate angiogenesis, vascular maturation, cardiac development and immunity, and are
important for directed cell movement.
Abstract
The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are differentially expressed, coupled to various G proteins, and regulate angiogenesis, vascular maturation, cardiac development and immunity, and are important for directed cell movement.
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