The frequency of reversible parkinsonism and cognitive decline associated with valproate treatment: a study of 364 patients with different types of epilepsy
AJ Ristić, N Vojvodić, S Janković, A Sindelić… - Epilepsia, 2006 - Wiley Online Library
AJ Ristić, N Vojvodić, S Janković, A Sindelić, D Sokić
Epilepsia, 2006•Wiley Online LibraryPurpose: We report the frequency of parkinsonism and cognitive decline (P/CD) in patients
treated with valproate (VPA) after 1 year of treatment and at least 1 year of follow‐up.
Methods: Three hundred sixty‐four patients with various epileptic syndromes and seizure
types were treated with VPA mono‐or polytherapy for more than 1 year. Results: We found
five cases of P/CD (1.37%; 95% CI, 0.18–2.56%). Among 140 patients with different adverse
effects (AEs) of VPA, P/CD were among the rarest in frequency but significant in terms of …
treated with valproate (VPA) after 1 year of treatment and at least 1 year of follow‐up.
Methods: Three hundred sixty‐four patients with various epileptic syndromes and seizure
types were treated with VPA mono‐or polytherapy for more than 1 year. Results: We found
five cases of P/CD (1.37%; 95% CI, 0.18–2.56%). Among 140 patients with different adverse
effects (AEs) of VPA, P/CD were among the rarest in frequency but significant in terms of …
Summary
Purpose: We report the frequency of parkinsonism and cognitive decline (P/CD) in patients treated with valproate (VPA) after 1 year of treatment and at least 1 year of follow‐up.
Methods: Three hundred sixty‐four patients with various epileptic syndromes and seizure types were treated with VPA mono‐ or polytherapy for more than 1 year.
Results: We found five cases of P/CD (1.37%; 95% CI, 0.18–2.56%). Among 140 patients with different adverse effects (AEs) of VPA, P/CD were among the rarest in frequency but significant in terms of drug discontinuation (five of 17).
Conclusions: Early identification of this type of AE and discontinuation of the drug led to complete recovery in affected patients.
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