[HTML][HTML] Chromosomal mosaicism in human blastocysts: a cytogenetic comparison of trophectoderm and inner cell mass after next-generation sequencing
E Chavli, M van den Born, C Eleveld, M Boter… - Reproductive …, 2022 - Elsevier
Research question What is the incidence of chromosomal mosaicism in human blastocysts
and can a single trophectoderm (TE) biopsy accurately predict the chromosomal constitution
of the inner cell mass (ICM)? Design Observational study in 46 surplus cryopreserved
preimplantation embryos of unknown chromosomal constitution. For each embryo, a TE
biopsy was performed and the ICM was collected separately. Both samples underwent next-
generation sequencing (NGS) for cytogenetic analysis and were classified as …
and can a single trophectoderm (TE) biopsy accurately predict the chromosomal constitution
of the inner cell mass (ICM)? Design Observational study in 46 surplus cryopreserved
preimplantation embryos of unknown chromosomal constitution. For each embryo, a TE
biopsy was performed and the ICM was collected separately. Both samples underwent next-
generation sequencing (NGS) for cytogenetic analysis and were classified as …