[HTML][HTML] Vulnerability of DHCR7+/− mutation carriers to aripiprazole and trazodone exposure
Z Korade, TC Genaro-Mattos, KA Tallman, W Liu… - Journal of lipid …, 2017 - ASBMB
Smith-Lemli-Opitz syndrome is a recessive disorder caused by mutations in 7-
dehydrocholesterol reductase (DHCR) 7 with a heterozygous (HET) carrier frequency of 1–
3%. A defective DHCR7 causes accumulation of 7-dehydrocholesterol (DHC), which is a
highly oxidizable and toxic compound. Recent studies suggest that several antipsychotics,
including the highly prescribed pharmaceuticals, aripiprazole (ARI) and trazodone (TRZ),
increase 7-DHC levels in vitro and in humans. Our investigation was designed to compare …
dehydrocholesterol reductase (DHCR) 7 with a heterozygous (HET) carrier frequency of 1–
3%. A defective DHCR7 causes accumulation of 7-dehydrocholesterol (DHC), which is a
highly oxidizable and toxic compound. Recent studies suggest that several antipsychotics,
including the highly prescribed pharmaceuticals, aripiprazole (ARI) and trazodone (TRZ),
increase 7-DHC levels in vitro and in humans. Our investigation was designed to compare …