[HTML][HTML] A hierarchical network of hypoxia-inducible factor and SMAD proteins governs procollagen lysyl hydroxylase 2 induction by hypoxia and transforming growth …
T Rosell-García, O Palomo-Álvarez… - Journal of Biological …, 2019 - ASBMB
Collagens are extracellular matrix (ECM) proteins that support the structural and
biomechanical integrity of many tissues. Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
(PLOD2) encodes the only lysyl hydroxylase (LH) isoform that specifically hydroxylates
lysine residues in collagen telopeptides, a post-translational modification required for the
formation of stabilized cross-links. PLOD2 expression is induced by hypoxia and
transforming growth factor-β1 (TGF-β1), well-known stimuli for the formation of a fibrotic …
biomechanical integrity of many tissues. Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
(PLOD2) encodes the only lysyl hydroxylase (LH) isoform that specifically hydroxylates
lysine residues in collagen telopeptides, a post-translational modification required for the
formation of stabilized cross-links. PLOD2 expression is induced by hypoxia and
transforming growth factor-β1 (TGF-β1), well-known stimuli for the formation of a fibrotic …