Trypanosoma brucei: biochemical and morphological studies of cytotoxicity caused by normal human serum
MR Rifkin - Experimental parasitology, 1984 - Elsevier
The biochemical and morphological events which accompany lysis of Trypanosoma brucei
by normal human serum have been described. The prelytic events include loss of infectivity
and rapid cation shifts across the cell membrane. This is followed by cell swelling, fraying of
the surface coat of the cell, loss of intracellular organelles, and eventually cell lysis. The data
presented are consistent with a colloid osmotic mechanism of lysis induced by irreversible
acute damage to the normal permeability properties of the trypanosome plasma membrane.
by normal human serum have been described. The prelytic events include loss of infectivity
and rapid cation shifts across the cell membrane. This is followed by cell swelling, fraying of
the surface coat of the cell, loss of intracellular organelles, and eventually cell lysis. The data
presented are consistent with a colloid osmotic mechanism of lysis induced by irreversible
acute damage to the normal permeability properties of the trypanosome plasma membrane.