Shp-1 mediates the antiproliferative activity of tissue inhibitor of metalloproteinase-2 in human microvascular endothelial cells
The tissue inhibitors of metalloproteinases (TIMPs) regulate matrix metalloproteinase activity
required for cell migration/invasion associated with cancer progression and angiogenesis.
TIMPs also modulate cell proliferation in vitro and angiogenesis in vivo independent of their
matrix metalloproteinase inhibitory activity. Here, we show that TIMP-2 mediates G 1 growth
arrest in human endothelial cells through de novo synthesis of the cyclin-dependent kinase
inhibitor p27 Kip1. TIMP-2-mediated inhibition of Cdk4 and Cdk2 activity is associated with …
required for cell migration/invasion associated with cancer progression and angiogenesis.
TIMPs also modulate cell proliferation in vitro and angiogenesis in vivo independent of their
matrix metalloproteinase inhibitory activity. Here, we show that TIMP-2 mediates G 1 growth
arrest in human endothelial cells through de novo synthesis of the cyclin-dependent kinase
inhibitor p27 Kip1. TIMP-2-mediated inhibition of Cdk4 and Cdk2 activity is associated with …
