[HTML][HTML] Biophysical and functional characterization of full-length, recombinant human tissue inhibitor of metalloproteinases-2 (TIMP-2) produced in Escherichia coli …
PT Wingfield, JK Sax, SJ Stahl, J Kaufman… - Journal of Biological …, 1999 - ASBMB
Matrix metalloproteinases (MMPs) function in the remodeling of the extracellular matrix that
is integral for many normal and pathological processes. The tissue inhibitor of
metalloproteinases family, including tissue inhibitor of metalloproteinases-2 (TIMP-2),
regulates the activity of these multifunctional metalloproteinases. TIMP family members are
proteinase inhibitors that contain six conserved disulfide bonds, one involving an amino-
terminal cysteine residue that is critical for MMP inhibitor activity. TIMP-2 has been …
is integral for many normal and pathological processes. The tissue inhibitor of
metalloproteinases family, including tissue inhibitor of metalloproteinases-2 (TIMP-2),
regulates the activity of these multifunctional metalloproteinases. TIMP family members are
proteinase inhibitors that contain six conserved disulfide bonds, one involving an amino-
terminal cysteine residue that is critical for MMP inhibitor activity. TIMP-2 has been …
