Olfactory deficit in idiopathic rapid eye movements sleep behavior disorder

ML Fantini, RB Postuma, J Montplaisir… - Brain research …, 2006 - Elsevier
INTRODUCTION: REM sleep behavior disorder (RBD) is a parasomnia characterized by a
loss of atonia and an increased phasic muscle activity during REM sleep. Idiopathic RBD
frequently herald an alpha-synucleinopathy, including such as Parkinson's disease (PD)
and dementia with Lewy Body (DLB). Pathological changes in the anterior olfactory nucleus
and olfactory loss occur very early in the course of PD and DLB. The aim of the study was to
assess olfactory function in a large group of idiopathic RBD patients. METHODS: Fifty-four …