[HTML][HTML] Transcriptome profiling from adipose tissue during a low-calorie diet reveals predictors of weight and glycemic outcomes in obese, nondiabetic subjects
C Armenise, G Lefebvre, J Carayol, S Bonnel… - The American journal of …, 2017 - Elsevier
Background A low-calorie diet (LCD) reduces fat mass excess, improves insulin sensitivity,
and alters adipose tissue (AT) gene expression, yet the relation with clinical outcomes
remains unclear. Objective We evaluated AT transcriptome alterations during an LCD and
the association with weight and glycemic outcomes both at LCD termination and 6 mo after
the LCD. Design Using RNA sequencing (RNAseq), we analyzed transcriptome changes in
AT from 191 obese, nondiabetic patients within a multicenter, controlled dietary intervention …
and alters adipose tissue (AT) gene expression, yet the relation with clinical outcomes
remains unclear. Objective We evaluated AT transcriptome alterations during an LCD and
the association with weight and glycemic outcomes both at LCD termination and 6 mo after
the LCD. Design Using RNA sequencing (RNAseq), we analyzed transcriptome changes in
AT from 191 obese, nondiabetic patients within a multicenter, controlled dietary intervention …