Chronic CRH depletion from GABAergic, long-range projection neurons in the extended amygdala reduces dopamine release and increases anxiety
Nature neuroscience, 2018•nature.com
The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system
has predominantly been studied in addiction and reward, while CRH–dopamine interactions
in anxiety are scarcely understood. We describe a new population of CRH-expressing,
GABAergic, long-range-projecting neurons in the extended amygdala that innervate the
ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons
are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine …
has predominantly been studied in addiction and reward, while CRH–dopamine interactions
in anxiety are scarcely understood. We describe a new population of CRH-expressing,
GABAergic, long-range-projecting neurons in the extended amygdala that innervate the
ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons
are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine …
Abstract
The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic system has predominantly been studied in addiction and reward, while CRH–dopamine interactions in anxiety are scarcely understood. We describe a new population of CRH-expressing, GABAergic, long-range-projecting neurons in the extended amygdala that innervate the ventral tegmental area and alter anxiety following chronic CRH depletion. These neurons are part of a distinct CRH circuit that acts anxiolytically by positively modulating dopamine release.
nature.com
