Parkinson's disease and cancer: two wars, one front

MJ Devine, H Plun-Favreau, NW Wood - Nature Reviews Cancer, 2011 - nature.com
MJ Devine, H Plun-Favreau, NW Wood
Nature Reviews Cancer, 2011nature.com
Parkinson's disease is caused by the premature death of neurons in the midbrain. By
contrast, cancer spawns from cells that refuse to die. We would therefore expect their
pathogenic mechanisms to be very different. However, recent genetic studies and emerging
functional work show that strikingly similar and overlapping pathways are involved in both
diseases. We consider these areas of convergence and discuss how insights from one
disease can inform us about, and possibly help us to treat, the other.
Abstract
Parkinson's disease is caused by the premature death of neurons in the midbrain. By contrast, cancer spawns from cells that refuse to die. We would therefore expect their pathogenic mechanisms to be very different. However, recent genetic studies and emerging functional work show that strikingly similar and overlapping pathways are involved in both diseases. We consider these areas of convergence and discuss how insights from one disease can inform us about, and possibly help us to treat, the other.
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