[HTML][HTML] Angiopoietin-like protein 8 differentially regulates ANGPTL3 and ANGPTL4 during postprandial partitioning of fatty acids [S]
YQ Chen, TG Pottanat, RW Siegel, M Ehsani… - Journal of Lipid …, 2020 - ASBMB
Angiopoietin-like protein (ANGPTL) 8 has been implicated in metabolic syndrome and
reported to regulate adipose FA uptake through unknown mechanisms. Here, we studied
how complex formation of ANGPTL8 with ANGPTL3 or ANGPTL4 varies with feeding to
regulate LPL. In human serum, ANGPTL3/8 and ANGPTL4/8 complexes both increased
postprandially, correlated negatively with HDL, and correlated positively with all other
metabolic syndrome markers. ANGPTL3/8 also correlated positively with LDL-C and blocked …
reported to regulate adipose FA uptake through unknown mechanisms. Here, we studied
how complex formation of ANGPTL8 with ANGPTL3 or ANGPTL4 varies with feeding to
regulate LPL. In human serum, ANGPTL3/8 and ANGPTL4/8 complexes both increased
postprandially, correlated negatively with HDL, and correlated positively with all other
metabolic syndrome markers. ANGPTL3/8 also correlated positively with LDL-C and blocked …