[HTML][HTML] An anti-ANGPTL3/8 antibody decreases circulating triglycerides by binding to a LPL-inhibitory leucine zipper-like motif
D Balasubramaniam, O Schroeder, AM Russell… - Journal of Lipid …, 2022 - ASBMB
Triglycerides (TG) are required for fatty acid transport and storage and are essential for
human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a
complex with ANGPTL3 that increases circulating TG by potently inhibiting LPL. We also
recently showed that the TG-lowering apolipoprotein A5 (ApoA5) decreases TG levels by
suppressing ANGPTL3/8-mediated LPL inhibition. To understand how LPL binds
ANGPTL3/8 and ApoA5 blocks this interaction, we used hydrogen-deuterium exchange …
human health. Angiopoietin-like-protein 8 (ANGPTL8) has previously been shown to form a
complex with ANGPTL3 that increases circulating TG by potently inhibiting LPL. We also
recently showed that the TG-lowering apolipoprotein A5 (ApoA5) decreases TG levels by
suppressing ANGPTL3/8-mediated LPL inhibition. To understand how LPL binds
ANGPTL3/8 and ApoA5 blocks this interaction, we used hydrogen-deuterium exchange …