Transgenic and gene disruption experiments in mice have revealed thatapolipoprotein (apo)
AV is a potent regulator of plasma triglyceride (TG) levels. To investigate the molecular basis
of apoA-V function, the ability ofisolated recombinant apoA-V to modulate lipoprotein lipase
(LPL) activity wasexamined in vitro. With three distinct lipid substrate particles, including very
low-density lipoprotein (VLDL), a TG/phospholipid emulsion,
ordimyristoylphosphatidylcholine liposomes, apoA-V had little effect on LPLactivity. In the …