Chromatin isolation by RNA purification (ChIRP)
Long noncoding RNAs are key regulators of chromatin states for important biological
processes such as dosage compensation, imprinting, and developmental gene expression
1, 2, 3, 4, 5, 6, 7. The recent discovery of thousands of lncRNAs in association with specific
chromatin modification complexes, such as Polycomb Repressive Complex 2 (PRC2) that
mediates histone H3 lysine 27 trimethylation (H3K27me3), suggests broad roles for
numerous lncRNAs in managing chromatin states in a gene-specific fashion 8, 9. While …
processes such as dosage compensation, imprinting, and developmental gene expression
1, 2, 3, 4, 5, 6, 7. The recent discovery of thousands of lncRNAs in association with specific
chromatin modification complexes, such as Polycomb Repressive Complex 2 (PRC2) that
mediates histone H3 lysine 27 trimethylation (H3K27me3), suggests broad roles for
numerous lncRNAs in managing chromatin states in a gene-specific fashion 8, 9. While …