Association between albuminuria, kidney function, and inflammatory biomarker profile in CKD in CRIC

J Gupta, N Mitra, PA Kanetsky, J Devaney… - Clinical journal of the …, 2012 - journals.lww.com
Results Plasma levels of IL-1β, IL-1RA, IL-6, TNF-α, hs-CRP, and fibrinogen were higher
among participants with lower levels of eGFR. Inflammation score was higher among those
with lower eGFR and higher UACR. In regression analysis adjusted for multiple covariates,
eGFR, cystatin C, and UACR were strongly associated with fibrinogen, serum albumin, IL-6,
and TNF-α. Each unit increase in eGFR, cystatin C, and UACR was associated with a−
1.2%(95% confidence interval,− 1.4,− 1), 64.9%(56.8, 73.3) and 0.6%(0.4, 0.8) change in IL …