[HTML][HTML] The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling
LC Russo, R Tomasin, IA Matos, AC Manucci… - Journal of Biological …, 2021 - ASBMB
SARS-CoV-2 nonstructural protein 3 (Nsp3) contains a macrodomain that is essential for
coronavirus pathogenesis and is thus an attractive target for drug development. This
macrodomain is thought to counteract the host interferon (IFN) response, an important
antiviral signalling cascade, via the reversal of protein ADP-ribosylation, a posttranslational
modification catalyzed by host poly (ADP-ribose) polymerases (PARPs). However, the main
cellular targets of the coronavirus macrodomain that mediate this effect are currently …
coronavirus pathogenesis and is thus an attractive target for drug development. This
macrodomain is thought to counteract the host interferon (IFN) response, an important
antiviral signalling cascade, via the reversal of protein ADP-ribosylation, a posttranslational
modification catalyzed by host poly (ADP-ribose) polymerases (PARPs). However, the main
cellular targets of the coronavirus macrodomain that mediate this effect are currently …