Human γδ T Lymphocytes Exert Natural and IL-2–Induced Cytotoxicity to Neuroblastoma Cells
KE Schilbach, A Geiselhart, JT Wessels… - Journal of …, 2000 - journals.lww.com
Human γδ T lymphocytes play an important role in nonadaptive reactions to infection and
early tumor defense. This is the first report that freshly isolated, native γδ T cells of some
healthy donors can kill human neuroblastoma cells to varying degrees. Their killing ability
was increased and maintained during expansion and cultivation with interleukin-2 (IL-2; 400
IU/mL) for as long as 30 days (100% specific lysis at an effector-to-target cell (E: T) ratio of
20: 1). γδ T lymphocytes without this spontaneous killing ability gained a specific cytolytic …
early tumor defense. This is the first report that freshly isolated, native γδ T cells of some
healthy donors can kill human neuroblastoma cells to varying degrees. Their killing ability
was increased and maintained during expansion and cultivation with interleukin-2 (IL-2; 400
IU/mL) for as long as 30 days (100% specific lysis at an effector-to-target cell (E: T) ratio of
20: 1). γδ T lymphocytes without this spontaneous killing ability gained a specific cytolytic …