The role of beta-cell dysfunction in early type 1 diabetes
EK Sims, RG Mirmira… - Current Opinion in …, 2020 - journals.lww.com
Current Opinion in Endocrinology, Diabetes and Obesity, 2020•journals.lww.com
This cumulative body of work shows clear evidence that β-cell stress, dysfunction, and death
are harbingers of impending T1D and likely contribute to progression of disease and insulin
deficiency. Treatment with agents targeting β-cell health could augment interventions with
immunomodulatory therapies but will need to be tested in intervention studies with
endpoints carefully designed to capture changes in β-cell function and health.
are harbingers of impending T1D and likely contribute to progression of disease and insulin
deficiency. Treatment with agents targeting β-cell health could augment interventions with
immunomodulatory therapies but will need to be tested in intervention studies with
endpoints carefully designed to capture changes in β-cell function and health.
Summary
This cumulative body of work shows clear evidence that β-cell stress, dysfunction, and death are harbingers of impending T1D and likely contribute to progression of disease and insulin deficiency. Treatment with agents targeting β-cell health could augment interventions with immunomodulatory therapies but will need to be tested in intervention studies with endpoints carefully designed to capture changes in β-cell function and health.
Lippincott Williams & Wilkins