Suppressor of cytokine signaling-1 peptidomimetic limits progression of diabetic nephropathy
C Recio, I Lazaro, A Oguiza… - Journal of the …, 2017 - journals.lww.com
Diabetes is the main cause of CKD and ESRD worldwide. Chronic activation of Janus
kinase and signal transducer and activator of transcription (STAT) signaling contributes to
diabetic nephropathy by inducing genes involved in leukocyte infiltration, cell proliferation,
and extracellular matrix accumulation. This study examined whether a cell-permeable
peptide mimicking the kinase-inhibitory region of suppressor of cytokine signaling-1
(SOCS1) regulatory protein protects against nephropathy by suppressing STAT-mediated …
kinase and signal transducer and activator of transcription (STAT) signaling contributes to
diabetic nephropathy by inducing genes involved in leukocyte infiltration, cell proliferation,
and extracellular matrix accumulation. This study examined whether a cell-permeable
peptide mimicking the kinase-inhibitory region of suppressor of cytokine signaling-1
(SOCS1) regulatory protein protects against nephropathy by suppressing STAT-mediated …