[HTML][HTML] Molecular markers and targeted therapy of skin rejection in composite tissue allotransplantation
T Hautz, B Zelger, J Grahammer, C Krapf… - American Journal of …, 2010 - Elsevier
Skin rejection remains a major hurdle in reconstructive transplantation. We investigated
molecular markers of skin rejection with particular attention to lymphocyte trafficking. Skin
biopsies (n= 174) from five human hand transplant recipients were analyzed for rejection,
characteristics of the infiltrate and lymphocytic adhesion markers. The cellular infiltrate
predominantly comprised CD3+ T cells. CD68, Foxp3 and indoleamine 2, 3-dioxygenase
expression and the CD4/CD8 increased with severity of rejection. Lymphocyte adhesion …
molecular markers of skin rejection with particular attention to lymphocyte trafficking. Skin
biopsies (n= 174) from five human hand transplant recipients were analyzed for rejection,
characteristics of the infiltrate and lymphocytic adhesion markers. The cellular infiltrate
predominantly comprised CD3+ T cells. CD68, Foxp3 and indoleamine 2, 3-dioxygenase
expression and the CD4/CD8 increased with severity of rejection. Lymphocyte adhesion …