Kinetics of the pregnancy-induced humoral and cellular immune response against the paternal HLA class I antigens of the child
CA van Kampen, MFJVV Maarschalk… - Human immunology, 2002 - Elsevier
Pregnancy can prime the maternal humoral immune response against paternal human
leukocyte antigens (HLA) of the child. Previous studies have reported that formation of
antibodies against inherited paternal HLA is associated with the presence of primed
cytotoxic T lymphocytes (CTLs) specific for these antigens. Recently, we reported that
primed CTLs can persist for more than 10 years after pregnancy even if the antibodies have
disappeared. In the present study we studied the kinetics of the pregnancy induced immune …
leukocyte antigens (HLA) of the child. Previous studies have reported that formation of
antibodies against inherited paternal HLA is associated with the presence of primed
cytotoxic T lymphocytes (CTLs) specific for these antigens. Recently, we reported that
primed CTLs can persist for more than 10 years after pregnancy even if the antibodies have
disappeared. In the present study we studied the kinetics of the pregnancy induced immune …
