[HTML][HTML] Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor
M Yang, W Ge, R Chowdhury, TDW Claridge… - Journal of biological …, 2011 - ASBMB
Factor-inhibiting hypoxia-inducible factor (FIH) catalyzes the β-hydroxylation of an
asparagine residue in the C-terminal transcriptional activation domain of the hypoxia
inducible factor (HIF), a modification that negatively regulates HIF transcriptional activity. FIH
also catalyzes the hydroxylation of highly conserved Asn residues within the ubiquitous
ankyrin repeat domain (ARD)-containing proteins. Hydroxylation has been shown to
stabilize localized regions of the ARD fold in the case of a three-repeat consensus ankyrin …
asparagine residue in the C-terminal transcriptional activation domain of the hypoxia
inducible factor (HIF), a modification that negatively regulates HIF transcriptional activity. FIH
also catalyzes the hydroxylation of highly conserved Asn residues within the ubiquitous
ankyrin repeat domain (ARD)-containing proteins. Hydroxylation has been shown to
stabilize localized regions of the ARD fold in the case of a three-repeat consensus ankyrin …
