[HTML][HTML] Cryptococcal transmigration across a model brain blood-barrier: evidence of the Trojan horse mechanism and differences between Cryptococcus neoformans …
TC Sorrell, PG Juillard, JT Djordjevic… - Microbes and …, 2016 - Elsevier
Abstract Cryptococcus neoformans (Cn) and Cryptococcus gattii (Cg) cause neurological
disease and cross the BBB as free cells or in mononuclear phagocytes via the Trojan horse
mechanism, although evidence for the latter is indirect. There is emerging evidence that Cn
and the North American outbreak Cg strain (R265) more commonly cause neurological and
lung disease, respectively. We have employed a widely validated in vitro model of the BBB,
which utilizes the hCMEC/D3 cell line derived from human brain endothelial cells (HBEC) …
disease and cross the BBB as free cells or in mononuclear phagocytes via the Trojan horse
mechanism, although evidence for the latter is indirect. There is emerging evidence that Cn
and the North American outbreak Cg strain (R265) more commonly cause neurological and
lung disease, respectively. We have employed a widely validated in vitro model of the BBB,
which utilizes the hCMEC/D3 cell line derived from human brain endothelial cells (HBEC) …
