Highlights•Aging Fancc−/− mice are prone to hematopoietic malignancies•Chromosomal
abnormalities in hematopoietic Fancc−/− cells precede the development of
leukemia•Fancc−/− leukemia can be successfully transplanted into healthy wt
recipientsFanconi anemia (FA) is an inherited disorder of genomic instability associated with
high risk of myelodysplasia and acute myeloid leukemia (AML). Young mice deficient in FA
core complex genes do not naturally develop cancer, hampering preclinical studies on …