Tet methylcytosine dioxygenase 2 (TET2) is one of the earliest and most frequently mutated
genes in clonal hematopoiesis of indeterminate potential (CHIP) and myeloid cancers,
including myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia
(CMML). TET2 catalyzes the oxidation of 5-methylcytosine to 5-hydroxymethylcytosine,
leading to DNA demethylation, and also affects transcription by recruiting histone modifiers.
Inactivating TET2 mutations cause epigenetic dysregulation, clonal hematopoietic stem cell …