Concise review: is cardiac cell therapy dead? Embarrassing trial outcomes and new directions for the future
Stem Cells Translational Medicine, 2018•academic.oup.com
Stem cell therapy is a promising strategy for tissue regeneration. The therapeutic benefits of
cell therapy are mediated by both direct and indirect mechanisms. However, the application
of stem cell therapy in the clinic is hampered by several limitations. This concise review
provides a brief introduction into stem cell therapies for ischemic heart disease. It
summarizes cell-based and cell-free paradigms, their limitations, and the benefits of using
them to target disease.
cell therapy are mediated by both direct and indirect mechanisms. However, the application
of stem cell therapy in the clinic is hampered by several limitations. This concise review
provides a brief introduction into stem cell therapies for ischemic heart disease. It
summarizes cell-based and cell-free paradigms, their limitations, and the benefits of using
them to target disease.
Abstract
Stem cell therapy is a promising strategy for tissue regeneration. The therapeutic benefits of cell therapy are mediated by both direct and indirect mechanisms. However, the application of stem cell therapy in the clinic is hampered by several limitations. This concise review provides a brief introduction into stem cell therapies for ischemic heart disease. It summarizes cell-based and cell-free paradigms, their limitations, and the benefits of using them to target disease.
Oxford University Press