Expression of ligands for Siglec-8 and Siglec-9 in human airways and airway cells
Y Jia, H Yu, SM Fernandes, Y Wei… - Journal of Allergy and …, 2015 - Elsevier
Background Balanced activation and inhibition of the immune system ensures pathogen
clearance while avoiding hyperinflammation. Siglecs, sialic acid–binding proteins found on
subsets of immune cells, often inhibit inflammation: Siglec-8 on eosinophils and Siglec-9 on
neutrophils engage sialoglycan ligands on airways to diminish ongoing inflammation. The
identities of human siglec ligands and their expression during inflammation are largely
unknown. Objective The histologic distribution, expression, and molecular characteristics of …
clearance while avoiding hyperinflammation. Siglecs, sialic acid–binding proteins found on
subsets of immune cells, often inhibit inflammation: Siglec-8 on eosinophils and Siglec-9 on
neutrophils engage sialoglycan ligands on airways to diminish ongoing inflammation. The
identities of human siglec ligands and their expression during inflammation are largely
unknown. Objective The histologic distribution, expression, and molecular characteristics of …