IL-25 enhances allergic airway inflammation by amplifying a TH2 cell–dependent pathway in mice
T Tamachi, Y Maezawa, K Ikeda, S Kagami… - Journal of allergy and …, 2006 - Elsevier
BACKGROUND: A novel IL-17 family cytokine, IL-25, has been reported to induce IL-4, IL-5,
and IL-13 production from undefined non-T/non-B cells and then induce TH2-type immune
responses. However, the roles of IL-25 in inducing allergic airway inflammation remain
unknown. OBJECTIVE: We sought to determine whether IL-25 is involved in causing allergic
airway inflammation. METHODS: We examined the expression of IL-25 mRNA in the lungs
of sensitized mice on antigen inhalation. We also examined the effect of IL-25 neutralization …
and IL-13 production from undefined non-T/non-B cells and then induce TH2-type immune
responses. However, the roles of IL-25 in inducing allergic airway inflammation remain
unknown. OBJECTIVE: We sought to determine whether IL-25 is involved in causing allergic
airway inflammation. METHODS: We examined the expression of IL-25 mRNA in the lungs
of sensitized mice on antigen inhalation. We also examined the effect of IL-25 neutralization …
