Background Premature infants often require oxygen supplementation and, therefore, are
exposed to oxidative stress. Following oxygen exposure, preterm infants frequently develop
chronic lung disease and have a significantly increased risk of asthma. Objective We sought
to identify the underlying mechanisms by which neonatal hyperoxia promotes asthma
development. Methods Mice were exposed to neonatal hyperoxia followed by a period of
room air recovery. A group of mice was also intranasally exposed to house dust mite …