Complement component C5 is not involved in scrapie pathogenesis
NA Mabbott, ME Bruce - Immunobiology, 2004 - Elsevier
During transmissible spongiform encephalopathy (TSE) infections the accumulation of
abnormal prion protein within the brain is often accompanied by severe neurodegeneration.
Studies have implicated complement, including the membrane attack complex (MAC, C5b–
C9), in inducing pathology in some neurodegenerative diseases. Recent studies show the
MAC is localized on neurons in the brains of TSE patients implicating complement-mediated
cell lysis in TSE neuropathology. To determine the role of the MAC in TSEs, we compared …
abnormal prion protein within the brain is often accompanied by severe neurodegeneration.
Studies have implicated complement, including the membrane attack complex (MAC, C5b–
C9), in inducing pathology in some neurodegenerative diseases. Recent studies show the
MAC is localized on neurons in the brains of TSE patients implicating complement-mediated
cell lysis in TSE neuropathology. To determine the role of the MAC in TSEs, we compared …