Heightened intrathecal release of proinflammatory cytokines in Creutzfeldt–Jakob disease
MK Sharief, A Green, JPR Dick, J Gawler… - Neurology, 1999 - AAN Enterprises
MK Sharief, A Green, JPR Dick, J Gawler, EJ Thompson
Neurology, 1999•AAN EnterprisesArticle abstract The authors report high intrathecal release of tumor necrosis factor alpha
(TNF-α) and interleukin (IL)-1β in five patients with sporadic or new-variant Creutzfeldt–
Jakob disease (CJD) without activation of the humoral or lymphocytic immune responses.
Increased release of TNF-α and IL-1β was also detected in some patients with progressive
dementias. CJD is associated with a local cerebral host response that involves the release
of proinflammatory cytokines.
(TNF-α) and interleukin (IL)-1β in five patients with sporadic or new-variant Creutzfeldt–
Jakob disease (CJD) without activation of the humoral or lymphocytic immune responses.
Increased release of TNF-α and IL-1β was also detected in some patients with progressive
dementias. CJD is associated with a local cerebral host response that involves the release
of proinflammatory cytokines.
Article abstract The authors report high intrathecal release of tumor necrosis factor alpha (TNF-α) and interleukin (IL)-1β in five patients with sporadic or new-variant Creutzfeldt–Jakob disease (CJD) without activation of the humoral or lymphocytic immune responses. Increased release of TNF-α and IL-1β was also detected in some patients with progressive dementias. CJD is associated with a local cerebral host response that involves the release of proinflammatory cytokines.
American Academy of Neurology