[HTML][HTML] RANKL (receptor activator of NFκB ligand) produced by osteocytes is required for the increase in B cells and bone loss caused by estrogen deficiency in mice
Y Fujiwara, M Piemontese, Y Liu, JD Thostenson… - Journal of Biological …, 2016 - ASBMB
The cytokine receptor activator of NFκB ligand (RANKL) produced by osteocytes is essential
for osteoclast formation in cancellous bone under physiological conditions, and RANKL
production by B lymphocytes is required for the bone loss caused by estrogen deficiency.
Here, we examined whether RANKL produced by osteocytes is also required for the bone
loss caused by estrogen deficiency. Mice lacking RANKL in osteocytes were protected from
the increase in osteoclast number and the bone loss caused by ovariectomy. Moreover …
for osteoclast formation in cancellous bone under physiological conditions, and RANKL
production by B lymphocytes is required for the bone loss caused by estrogen deficiency.
Here, we examined whether RANKL produced by osteocytes is also required for the bone
loss caused by estrogen deficiency. Mice lacking RANKL in osteocytes were protected from
the increase in osteoclast number and the bone loss caused by ovariectomy. Moreover …