[HTML][HTML] Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cells
S Gines, E Ivanova, IS Seong, CA Saura… - Journal of Biological …, 2003 - ASBMB
Huntington's disease features the loss of striatal neurons that stems from a disease process
that is initiated by mutant huntingtin. Early events in the disease cascade, which predate
overt pathology in Hdh CAG knock-in mouse striatum, implicate enhanced N-methyl-d-
aspartate (NMDA) receptor activation, with excitotoxity caused by aberrant Ca 2+ influx.
Here we demonstrate in precise genetic Huntington's disease mouse and striatal cell
models that these early phenotypes are associated with activation of the Akt pro-survival …
that is initiated by mutant huntingtin. Early events in the disease cascade, which predate
overt pathology in Hdh CAG knock-in mouse striatum, implicate enhanced N-methyl-d-
aspartate (NMDA) receptor activation, with excitotoxity caused by aberrant Ca 2+ influx.
Here we demonstrate in precise genetic Huntington's disease mouse and striatal cell
models that these early phenotypes are associated with activation of the Akt pro-survival …