Mapping cis-and trans-chromatin interaction networks using chromosome conformation capture (3C)
A Miele, J Dekker - The nucleus, 2008 - Springer
A Miele, J Dekker
The nucleus, 2008•SpringerExpression of genes can be controlled by regulatory elements that are located at large
genomic distances from their target genes (in cis), or even on different chromosomes (in
trans). Regulatory elements can act at large genomic distances by engaging in direct
physical interactions with their target genes resulting in the formation of chromatin loops.
Thus, genes and their regulatory elements come in close spatial proximity irrespective of
their relative genomic positions. Analysis of interactions between genes and elements will …
genomic distances from their target genes (in cis), or even on different chromosomes (in
trans). Regulatory elements can act at large genomic distances by engaging in direct
physical interactions with their target genes resulting in the formation of chromatin loops.
Thus, genes and their regulatory elements come in close spatial proximity irrespective of
their relative genomic positions. Analysis of interactions between genes and elements will …
Abstract
Expression of genes can be controlled by regulatory elements that are located at large genomic distances from their target genes (in cis), or even on different chromosomes (in trans). Regulatory elements can act at large genomic distances by engaging in direct physical interactions with their target genes resulting in the formation of chromatin loops. Thus, genes and their regulatory elements come in close spatial proximity irrespective of their relative genomic positions. Analysis of interactions between genes and elements will reveal which elements regulate each gene, and will provide fundamental insights into the spatial organization of chromosomes in general.
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