Insulin and glucagon secretion in swimming mice: effects of adrenalectomy and chemical sympathectomy
S Karlsson, B Ahrén - Journal of the autonomic nervous system, 1991 - Elsevier
Swimming-stress is known to inhibit glucose-stimulated insulin secretion and stimulate
glucagon secretion. In the present study, in mice, we investigated the relative contribution of
sympathetic nerves and the adrenals to these effects. Mice were pretreated either with
adrenalectomy or chemical sympathectomy induced by iv injection of 6-hydroxydopamine (6-
OHDA), which destroys sympathetic nerve terminals. Two days later, the mice were injected
iv with either glucose (5.6 mmol/kg) or saline, immediately before being subjected to 2 min …
glucagon secretion. In the present study, in mice, we investigated the relative contribution of
sympathetic nerves and the adrenals to these effects. Mice were pretreated either with
adrenalectomy or chemical sympathectomy induced by iv injection of 6-hydroxydopamine (6-
OHDA), which destroys sympathetic nerve terminals. Two days later, the mice were injected
iv with either glucose (5.6 mmol/kg) or saline, immediately before being subjected to 2 min …