[HTML][HTML] The human growth hormone gene cluster locus control region supports position-independent pituitary-and placenta-specific expression in the transgenic …
Y Su, SA Liebhaber, NE Cooke - Journal of Biological Chemistry, 2000 - ASBMB
The human growth hormone (hGH) cluster contains five genes. The hGH-N gene is
predominantly expressed in pituitary somatotropes, whereas the remaining four genes, the
chorionic somatomammotropin genes (hCS-L, hCS-A, and hCS-B) and hGH-V, are
expressed selectively in the placenta. In contrast, the mouse genome contains a single
pituitary-specific GH gene and lacks any GH-related CS genes. Activation of the hGH
transgene in the mouse is dependent on its linkage to a previously described locus control …
predominantly expressed in pituitary somatotropes, whereas the remaining four genes, the
chorionic somatomammotropin genes (hCS-L, hCS-A, and hCS-B) and hGH-V, are
expressed selectively in the placenta. In contrast, the mouse genome contains a single
pituitary-specific GH gene and lacks any GH-related CS genes. Activation of the hGH
transgene in the mouse is dependent on its linkage to a previously described locus control …