Differential placental hormone gene expression during pregnancy in a transgenic mouse containing the human growth hormone/chorionic somatomammotropin locus
Y Jin, SY Lu, A Fresnoza, KA Detillieux, ML Duckworth… - Placenta, 2009 - Elsevier
The human (h) growth hormone/chorionic somatomammotropin (GH/CS) gene locus
presents a unique model to gain insight into the molecular mechanisms that have allowed a
closely related family of genes to be expressed in two distinct cell lineages/tissues: pituitary
somatotrophs and placental syncytiotrophoblasts. However, studies of external factors that
regulate gene expression have been somewhat limited by (i) a lack of human cell lines
expressing endogenous GH or CS appropriately; and (ii) the fact that the GH/CS locus is …
presents a unique model to gain insight into the molecular mechanisms that have allowed a
closely related family of genes to be expressed in two distinct cell lineages/tissues: pituitary
somatotrophs and placental syncytiotrophoblasts. However, studies of external factors that
regulate gene expression have been somewhat limited by (i) a lack of human cell lines
expressing endogenous GH or CS appropriately; and (ii) the fact that the GH/CS locus is …